Educate, Uplift and Inspire
We believe in total transparency, particularly when it comes to consumables. Cardio Miracle’s commitment to our customers is full disclosure of our ingredients.
Our formula is a five-year labor of love founded on the Nobel laureate, Louis J. Ignarro’s discovery of nitric oxide’s cell-signaling action. Cardio Miracle incorporates the latest research findings on enhancing and increasing nitric oxide’s absorbability. What began as a mission to create the finest nitric oxide booster in the world soon became the development of a potent health enhancing drink that also supports critical chemical processes in the body that destroy pathogenic organisms and support the body’s immune system against attack.
Five years of laboratory testing was necessary in order to achieve a world-class product worthy of the founder’s approval. We pride ourselves on the exclusive use of the most absorbable and active form of vitamins and minerals, but also the highest quality ingredients.
We encourage label reading and self-education before considering any supplement, but most especially a nitric oxide booster - due to the complexity of benefits and side effects from this miraculous cell-signaling molecule.
Cardio Miracle is a formula of the highest standard, worthy of human consumption and we guarantee our customers total satisfaction. We aim to change the world, one life at a time.
Click on any ingredient below for details on its purpose.
- L-Arginine (AAKG)
- Fruit, Fiber/Prebiotic & Vegetable Blend – Grape Seed Extract
- Pine Bark
- Watermelon Extract
- Hawthorn Berries
- Proprietary Blend — Pomegranate fruit extract/beet root crystals
- Ionic Trace Minerals
- Vitamin C
- Vitamin K2 as MK-7
- Vitamin D3
- Vitamin B Complex
- Vitamin B6 (Pyridoxine HCI)
- Vitamin B12 (as Methlycobalamin)
- Natural Vitamin E (as gamma tocopherol)
- Other Ingredients — Stevia / natural flavors
- Orgen B
Cardio Miracle™ contains AAKG
A 100% blend of pharmaceutical grade L-arginine and Alpha-Ketoglutrate.
Arginine AAKG gives you all the endothelial- lining-support and vasodilation properties of arginine plus a number of benefits from alpha- ketoglutarate (AKG), such as increased arginine stability, bioavailability, and absorption.
Furthermore, alpha-ketoglutarate will serve as a transport medium for arginine, for optimal synthesis. Beyond this, AAKG supports the bodies endogenous production of glutamine and glutamic acid, both important for muscle growth and for the immune system.
AKG also has been shown to bind to toxic ammonia in muscle cells, in the liver, and in the brain, thereby converting ammonia into glutamic acid improving glutamine levels and assisting in elimination of toxic ammonia from the body. Lastly, as a Krebs Cycle intermediate, AKG has shown to have positive effects on VO2 Max and energy metabolism in muscle cells, and is consequently a potent ergogenic.
Poor absorption can limit L-arginine’s benefits
Although this powerful Amino Acid has been shown to provide a large number of health benefits, it has one significant issue; our body has a very difficult time digesting and absorbing L-arginine. One reason is that the intestine and liver contain the enzyme arginase that breaks down L- arginine.
Clinical Studies have suggested that in many cases our bodies are able to utilize less than 50% of the L-arginine we consume. The remainder of the L-arginine product is excreted from our body in the form of waste. The low percentage of absorption is what forces hospitals to provide patients with L-arginine intravenously instead of orally. Arginine in the AKG form utilizes a different enzymatic pathway for absorption than regular L-arginine, which allows our body to absorb 90% of the form AAKG.
L-Citrulline is a precursor to arginine in the body. L-citrulline converts to arginine which then converts to Nitric Oxide (NO). It essentially acts like a time-released L-arginine extending the life of L-arginine so it can continue to trigger the production of nitric oxide.
Citrulline bypasses the liver and unlike arginine, is not subject to breakdown by arginase. After supplementation, L-citrulline is converted into arginine in the kidneys. Despite claims that L-citrulline alone is sufficient to raise NO levels this position was contradicted by a 2014 Japanese study that showed the combination of both L-arginine and L-citrulline raises plasma L-arginine levels, and causes a significantly greater increase in plasma nitric oxide.
This means L-citrulline supplementation improves the ammonia recycling process and nitric oxide metabolism. L-citrulline is also used to alleviate erectile dysfunction caused by high blood pressure.
L-arginine and L-ornithine lose absorption value when supplemented in doses of 10g or more, which can result in diarrhea. L-Citrulline does not have this side-effect, but rather increases plasma levels of all three amino acids.
L-citrulline is found in watermelon rinds (not as much in the red stuff). Cardio Miracle’s L-citrulline is sourced from watermelon rinds.
L-ornithine’s synergistic relationship with the anti-aging amino acid L-arginine increases strength and endurance according to a recent study. And according to a study in Nutrition Research, people who took ornithine were less fatigued from exercise than were people who took a placebo. The study found that ornithine helps the body use energy and combat fatigue more efficiently. Scientist believe ornithine supports proper liver function, prevents fatigue, and boosts performance during prolonged exercise. L-ornithine provides athletic support by helping flush out excess ammonia and nitrogen from muscles during exercise.
Some research even suggests that ornithine together with l-arginine may help increase levels of human growth hormone
One clinical trial found that when burn patients took 10-30 grams of ornithine alpha ketoglutarate, OKG, daily they experienced faster healing. In addition, cancer patients taking OKG experienced faster recoveries as well.
AstraGin™ is a proprietary ingredient that holds a U.S. patent for “method for enhancing nutrient absorption.” AstraGin™ has been shown to support increased arginine absorption by 67% and L-citrulline absorption by 45% - as well as minerals and vitamins.
AstraGin™ is a natural compound composed of highly fractionated astragalus and Panax Notoginseng. AstraGin™ has been designed and formulated to assist in the overall absorption of the cationic amino acids L-arginine and L-citrulline.
AstraGin™ has been clinically shown to increase the absorption of L-arginine by 62% We use AstraGin™ as part of a group of ingredients to naturally increase the dosage by increasing the bioavailability of amino acids, vitamins and minerals. This translates to multiplying the dosage of the ingredients in our product up to 5 times.
For example, vitamin B12 contains 250 mcg. Due to the higher level of bioavailability due to AstraGin™ absorption enhancement, the dosage translates to a value of up to 1000 mcg.
Fruit, Fiber/Prebiotic & Vegetable Blend – Grape Seed Extract
Cardio Miracle utilizes a very high quality grape seed extract with a high concentration of active polyphenols and with antioxidant properties. Grape seed extract helps to support nitric oxide synthase in the endothelium, supporting healthy blood pressure. Grape seed extract is a flavonoid that has a high affinity for collagen structures, including those of your arteries and heart. It is known to support the structural integrity of tissue, helping in some instances to minimize physical wear and tear in the body. Studies may suggest that it may also help strengthen vein health and skin structure.
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Pycnogenol was shown to improve blood glucose control in clinical studies. It also supported increased blood flow when combined with nitric oxide boosting L-arginine. This cardioprotective effect is greatly enhanced when Pycnogenol and L-arginine AKG is combined and may also help with erectile dysfunction.
The combination of L-arginine and GSE may enhance muscle function and performance; and when combined with other synergistic antioxidants like Pine Bark, Vitamins C and E, and Resveratrol it becomes a powerhouse of benefits for repairing and maintaining cardiovascular health.
For those who don’t fancy munching on watermelon rind, watermelon extract is an excellent source of L- citrulline, an active precursor to L-arginine. Because it is also rich in lycopene, lutein, and beta carotene, Watermelon has been shown to support increased levels of antioxidants in blood plasma.
Resveratrol (Polygonum Cuspidatum)
Resveratrol is found in some red wines and is believed to be a key reason the French can eat high amounts of fat and still maintain a healthy heart. Research shows that Resveratrol can act as a protector against some metabolic stressors associated with a high fat diet. Resveratrol is a potent cardiovascular antioxidant, working synergistically as part of the antioxidant network. It has been shown to enhance the function of an important cellular antioxidant enzyme called MnSOD, which helps support mitochondria to function as it is designed to do.
Hawthorn berry is one of the most potent antioxidants known for healing several parts of the body. It is packed with beneficial flavonoids, saponins, phenolic acids, oligomeric proanthocyanins (OPCs), quercetin, procyonid, malic acid, and citric acid and other phytonutrients that act as potent antioxidants and stimulate internal healing mechanisms.
Hawthorn berry helps protect against the formation of plaque, which leads to a health problem known as atherosclerosis. One animal study found that extracts of the plant given to rabbits with high cholesterol helped reduce cholesterol levels. Studies to determine if hawthorn will confer the same effects in people are needed, but the results are promising.
Several studies have similar conclusions that hawthorn significantly improved heart function and patients' ability to exercise as well as shortness of breath fatigue.
Several studies have found that hawthorn may promote balanced blood pressure. Those who received the hawthorn preparation experienced improved blood flow to the heart and were also able to exercise for longer periods of time without suffering from chest pain.
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Proprietary Blend — Pomegranate fruit extract/beet root crystals
Recently, scientists discovered that pomegranate juice may enhance the bioactivity of nitric oxide synthase in endothelial cells. Furthermore, pomegranate’s antioxidant properties help to protect nitric oxide from oxidative destruction. Pomegranate juice has also been shown to support the positive expression of nitric oxide synthase in both healthy and unhealthy blood vessels.
According to a study published in a June 2010 issue of Science Daily, the nitrates in beetroot juice can be beneficial because they have been shown to increase the amount of nitric oxide in the blood and consequently widen blood vessels, support circulation, and support normal blood pressure.
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Dietary fibers can act by changing the nature of the contents of the gastrointestinal tract. In particular prebiotic fibers have had a lot of attention recently because healthcare professionals are recognizing how important they are for balance within the human microbiome. Soluble and insoluble fibers encourage healthy flora in the gastrointestinal tract.
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Ionic Trace Minerals
Ionic Trace Minerals help to support normal PH balance within the body which facilitates greater absorption of Nitric Oxide. Ionic minerals are easily and quickly absorbed and taken into the cells that line the intestinal tract.
These minerals may are often employed in the body’s many physiologic activities, including nutrient transport, enzyme reactions, metabolism help, and immune system support.
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Mothers have been giving Vitamin C to their children ever since Linus Pauling touted its nearly universal benefits. Turns out Mr. Pauling and your mother weren’t wrong; research in this century shows that Vitamin C helps support endothelial Nitric Oxide production. Increased Nitric Oxide levels support healthy endothelial function, and even supports higher l-citrulline levels.
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Vitamin K2 as MK-7
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Vitamin D is sometimes called the sunshine vitamin. Studies show that moderate sun exposure will increase the body’s natural vitamin D, providing a boost in energy and a feeling of well-being. Some research has suggested that this may be because of vitamin D’s role in Nitric Oxide production. Studies may suggest that insufficient vitamin D may reduce the bioavailability of Nitric Oxide in veins and arteries. The CDC reports that vitamin D deficiency has risen to 25% of the population. Many researchers believe this deficiency may contribute to increases in blood pressure and cardiovascular disease risk. One serving of Cardio Miracle helps support normal vitamin D levels associated with optimal Nitric Oxide production.
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Vitamin B Complex
Besides helping sustain normal metabolic function the B vitamins play an important role in regulating homocysteine levels in the blood. A New York study showed that homocysteine levels greater than 1200 microM “produced significant indirect suppression of eNOS activity.” The B vitamin group also helps regulate other chemicals that directly affect mitochondrial activity believed to eventually induce NO synthesis.
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Magnesium is involved in many vital biochemical reactions. It has an anti-arrhythmic effect and can influence blood pressure levels. Improving magnesium levels can also help improve the production and release of nitric oxide.
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Vitamin B12 (as Methlycobalamin)
Vitamin B12 is an essential nutrient for the body, and is needed to protect DNA and RNA, support energy, protect nerve and brain cells, stimulate serotonin production, contribute to red blood cell formation, maintain skin, support digestion, and support immune function.
Why Vitamin B12 is so important for cardiovascular function
One of the primary reactions of methylcobalamin in the body is to convert homocysteine to methionine - high homocysteine levels are undesirable and known to be an indicator of heart disease and stroke risk due to the fact free homocysteine in the blood causes atherosclerosis and venous thrombosis, putting strain on the vascular system and the heart. Vitamin B12 plays the part of regulating the levels of this hormone in the blood since it is produced whenever amino acids are broken down.
In addition, the conversion of homocysteine to methionine reduces the potential for damage because the methionine is the precursor to the super-antioxidant glutathione. Glutathione is the body's main antioxidant, protecting our cells from damage as well as the body’s master detoxifier.
There are some things that should be cleared up about vitamin B supplementation. Many companies opt to use the cheapest form which is produced in a lab. It’s called cyanocobalamin and it’s chemically synthesized, whereas the other form known as methylcobalamin is found in animal based foods and occurs naturally.
Why it’s important to know the difference between Methylcobalamin and Cyanocobalamin?
Cyanocobalamin contains a cyanide molecule. Although the amount of cyanide in a normal B12 supplement is small, your body still has to eliminate this compound. Methylcobalamin has a methyl group (just carbon and hydrogen) and it’s the methyl-compound that the human body needs to function properly.
Methylcobalamin is the superior vitamin B12 form.
Methylcobalamin is the most bio-available form of Vitamin B12, and it remains in the body for a longer period of time and at higher levels than cyanocobalamin. The body is supplied with vitamin B12 for longer with methylcobalamin than with cyanocobalamin. In addition, studies show methylcobalamin significantly improves visual accommodation, while cyanocobalamin is ineffective.
The most well studied use of methylcobalamin is focused on sleep, it appears that methylcobalamin is needed for the synthesis of melatonin. The research indicates that methylcobalamin can modulate melatonin secretion, enhance light-sensitivity, and normalize circadian rhythm.
Lastly, certain forms of vitamin B12 are essential for pain management and without it, the body would be unable to cope. The methyl form of vitamin B12 is needed to suppress the cytokine production and studies show it has the same pain reducing effect in patients that suffer from arthritis. Back to list.
Natural Vitamin E (as gamma tocopherol)
Vitamin E, and especially Vitamin E expressed as gamma tocopherol, is a potent antioxidant and provides Nitric Oxide support. Vitamin E helps support the minimization of cell-damaging free radicals on the endothelial lining thus and has been shown to support higher levels of nitric oxide.Back to list.
Other Ingredients — Stevia / natural flavors
Orgen-B is a blend of Certified Organic Guava (Psidium guajava), Mango (Mangifera indica), and Lemon (Citrus limon) extracts). 600 mg of Orgen-B offers Organic, Kosher and 100% Natural Vitamin B1, B2, B3, B5, B6, B9 more than RDA, along with co-nutrients.Back to list.
Turmeric is a rhizomatous herbaceous perennial flowering plant of the ginger family, Zingiberaceae. It is native to the Indian subcontinent and Southeast Asia, and requires temperatures between 20 and 30 °C (68 and 86 °F) and a considerable amount of annual rainfall to thrive.Back to list.
Astaxanthin is a keto-carotenoid. It belongs to a larger class of chemical compounds known as terpenes (as a tetraterpenoid) built from five carbon precursors, isopentenyl diphosphate, and dimethylallyl diphosphate.Back to list.